Author

I. A. Showpnil

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Approach:statistical model· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

C. Taslim· 3 shared E. R. Theisen· 3 shared J. C. Crow· 3 shared J. Selich-Anderson· 3 shared S. L. Lessnick· 3 shared M. A. Boone· 2 shared A. Bayanjargal· 1 shared B. D. Sunkel· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

C. Taslim

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3 papers

Recent·Most cited

DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

A. Bayanjargal, C. Taslim, I. A. Showpnil, J. Selich-Anderson, J. C. Crow, R. Zhou, S. L. Lessnick, E. R. Theisen

This study investigates the role of the DBD-4 helix in EWSR1::FLI1's binding to GGAA microsatellites, showing its importance in genome regulation and oncogenic transformation in Ewing sarcoma.

bioRxiv · Jan 31, 2024Cancer Biology

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma

I. A. Showpnil, J. Selich-Anderson, C. Taslim, M. A. Boone, J. C. Crow, E. R. Theisen, S. L. Lessnick

This study identifies how EWS/FLI fusion proteins alter chromatin structure and transcription in Ewing sarcoma, highlighting their role in reprogramming 3D chromatin to drive transcriptional changes.

bioRxiv · Sep 30, 2021Cancer Biology

The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma

M. A. Boone, C. Taslim, J. C. Crow, J. Selich-Anderson, I. A. Showpnil, B. D. Sunkel, M. Wang, B. Z. Stanton, E. R. Theisen, S. L. Lessnick

This study identifies the specific FLI regions in EWS/FLI critical for oncogenic transformation in Ewing sarcoma, showing the DNA-binding domain and a carboxyl-terminal alpha-helix are essential for transcriptional regulation and tumorigenesis.

bioRxiv · Oct 29, 2020Cancer Biology