Author

C. Taslim

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Biology Disciplines

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Cancer Biology· 8

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Assay:bulk RNA-seq· 4 Assay:ChIP-seq· 4 Research Focus:chromatin & epigenetic regulation· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2

Frequent Co-Authors

E. R. Theisen· 6 shared J. Selich-Anderson· 5 shared S. L. Lessnick· 5 shared J. C. Crow· 4 shared I. A. Showpnil· 3 shared M. V. Cannon· 3 shared M. Wang· 3 shared A. Bayanjargal· 2 shared

Activity by Year

2020-2024 · peak 3/yr

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10 top collaborators · 35 mutual co-author links

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6 shared papersCancer Biology

E. R. Theisen

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8 papers

Recent·Most cited

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

J. Kucinski, A. Tallan, C. Taslim, M. Wang, M. V. Cannon, K. M. Silvius, B. Z. Stanton, G. C. Kendall

The paper identifies PAX3::FOXO1's pioneer function through partial/homeobox motif recognition and its role in initiating neural transcriptional programs in rhabdomyosarcoma.

bioRxiv · Jul 12, 2024Cancer Biology

Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins

G. C. Rask, C. Taslim, A. Bayanjargal, M. V. Cannon, J. Selich-Anderson, J. Crow, A. Duncan, E. R. Theisen

This study shows seclidemstat inhibits the transcriptional activity of multiple FET fusion oncoproteins in vitro, suggesting it as a promising treatment for FET-rearranged sarcomas.

bioRxiv · May 19, 2024 · PreprintCancer Biology

DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

A. Bayanjargal, C. Taslim, I. A. Showpnil, J. Selich-Anderson, J. C. Crow, R. Zhou, S. L. Lessnick, E. R. Theisen

This study investigates the role of the DBD-4 helix in EWSR1::FLI1's binding to GGAA microsatellites, showing its importance in genome regulation and oncogenic transformation in Ewing sarcoma.

bioRxiv · Jan 31, 2024Cancer Biology

Mitochondrial Dysfunction is a Driver for SP-2509 Drug Resistance in Ewing Sarcoma

E. J. P. Tokarsky, J. C. Crow, L. M. Guenther, J. Sherman, C. Taslim, G. Alexe, K. I. Pishas, G. Rask, B. S. Justis, A. Kasumova, K. Stegmaier, S. L. Lessnick, E. R. Theisen

The paper identifies mitochondrial dysfunction as a mechanism of resistance to the LSD1 inhibitor SP-2509 in Ewing sarcoma and suggests combining LSD1 inhibitors with mitochondrial-targeting agents.

bioRxiv · Dec 13, 2021Cancer Biology

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma

I. A. Showpnil, J. Selich-Anderson, C. Taslim, M. A. Boone, J. C. Crow, E. R. Theisen, S. L. Lessnick

This study identifies how EWS/FLI fusion proteins alter chromatin structure and transcription in Ewing sarcoma, highlighting their role in reprogramming 3D chromatin to drive transcriptional changes.

bioRxiv · Sep 30, 2021Cancer Biology

Chromatin profiling reveals reorganization of lysine specific demethylase 1 by an oncogenic fusion protein

E. R. Theisen, J. Selich-Anderson, K. R. Miller, J. M. Tanner, C. Taslim, K. I. Pishas, S. Sharma, S. L. Lessnick

The paper shows EWS/FLI fusion protein alters LSD1 distribution and function, impacting enhancer landscapes and gene activation in Ewing sarcoma.

Epigenetics · Apr 3, 2021Peer-reviewedCancer Biology

Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization

S. Rajan, E. Franz, C. A. McAloney, T. A. Vetter, M. Cam, A. C. Gross, C. Taslim, M. Wang, M. V. Cannon, A. Oles, R. D. Roberts

This study shows osteosarcoma tumors retain transcriptional heterogeneity during bone and lung colonization despite selective pressures.

bioRxiv · Nov 3, 2020 · PreprintCancer Biology

The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma

M. A. Boone, C. Taslim, J. C. Crow, J. Selich-Anderson, I. A. Showpnil, B. D. Sunkel, M. Wang, B. Z. Stanton, E. R. Theisen, S. L. Lessnick

This study identifies the specific FLI regions in EWS/FLI critical for oncogenic transformation in Ewing sarcoma, showing the DNA-binding domain and a carboxyl-terminal alpha-helix are essential for transcriptional regulation and tumorigenesis.

bioRxiv · Oct 29, 2020Cancer Biology