Author

E. R. Theisen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. Taslim· 4 shared S. L. Lessnick· 4 shared J. C. Crow· 3 shared J. Selich-Anderson· 3 shared I. A. Showpnil· 2 shared K. I. Pishas· 2 shared M. A. Boone· 2 shared A. Kasumova· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersCancer Biology

C. Taslim

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4 papers

Recent·Most cited

Cancer BiologybioRxivDec 13, 2021

Mitochondrial Dysfunction is a Driver for SP-2509 Drug Resistance in Ewing Sarcoma

E. J. P. Tokarsky, J. C. Crow, L. M. Guenther…·E. R. Theisen

The paper identifies mitochondrial dysfunction as a mechanism of resistance to the LSD1 inhibitor SP-2509 in Ewing sarcoma and suggests combining LSD1 inhibitors with mitochondrial-targeting agents.

DOI 10.1158/1541-7786.mcr-22-0027

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivSep 30, 2021

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma

I. A. Showpnil, J. Selich-Anderson, C. Taslim…·S. L. Lessnick

This study identifies how EWS/FLI fusion proteins alter chromatin structure and transcription in Ewing sarcoma, highlighting their role in reprogramming 3D chromatin to drive transcriptional changes.

DOI 10.1093/nar/gkac747

humanChIP-seq

𝕏 PostBluesky

Cancer BiologyEpigeneticsPeer-reviewedApr 3, 2021

Chromatin profiling reveals reorganization of lysine specific demethylase 1 by an oncogenic fusion protein

E. R. Theisen, J. Selich-Anderson, K. R. Miller…·S. L. Lessnick

The paper shows EWS/FLI fusion protein alters LSD1 distribution and function, impacting enhancer landscapes and gene activation in Ewing sarcoma.

DOI 10.1080/15592294.2020.1805678

humanChIP-seq

𝕏 PostBluesky

Cancer BiologybioRxivOct 29, 2020

The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma

M. A. Boone, C. Taslim, J. C. Crow…·S. L. Lessnick

This study identifies the specific FLI regions in EWS/FLI critical for oncogenic transformation in Ewing sarcoma, showing the DNA-binding domain and a carboxyl-terminal alpha-helix are essential for transcriptional regulation and tumorigenesis.

DOI 10.1038/s41388-021-01876-5

humanbulk RNA-seq

𝕏 PostBluesky