Author

I. Alexandrov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

G. Gerlitz· 1 shared J. Yaglom· 1 shared L. Kaczmarczyk· 1 shared M. Salmon-Divon· 1 shared M. Y. Sherman· 1 shared S. Kumar· 1 shared S. Patel· 1 shared V. Gahramanov· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

G. Gerlitz

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1 paper

Recent·Most cited

Evolution of resistance to Irinotecan in cancer cells involves generation of topoisomerase-guided mutations in non-coding genome that reduce the chances of DNA breaks

S. Kumar, V. Gahramanov, S. Patel, J. Yaglom, L. Kaczmarczyk, I. Alexandrov, G. Gerlitz, M. Salmon-Divon, M. Y. Sherman

The paper investigates how cancer cells develop resistance to irinotecan by generating topoisomerase-guided mutations in non-coding regions, reducing DNA breaks and increasing drug resistance.

bioRxiv · Nov 26, 2021Cancer Biology