Author

J. Yaglom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

M. Y. Sherman· 2 shared S. Kumar· 2 shared S. Patel· 2 shared A. Hesin· 1 shared G. Gerlitz· 1 shared I. Alexandrov· 1 shared L. Kaczmarczyk· 1 shared M. Salmon-Divon· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

M. Y. Sherman

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2 papers

Recent·Most cited

Evolution of resistance to Irinotecan in cancer cells involves generation of topoisomerase-guided mutations in non-coding genome that reduce the chances of DNA breaks

S. Kumar, V. Gahramanov, S. Patel, J. Yaglom, L. Kaczmarczyk, I. Alexandrov, G. Gerlitz, M. Salmon-Divon, M. Y. Sherman

The paper investigates how cancer cells develop resistance to irinotecan by generating topoisomerase-guided mutations in non-coding regions, reducing DNA breaks and increasing drug resistance.

bioRxiv · Nov 26, 2021Cancer Biology

eIF2α integrates proteotoxic signals both from ER and cytoplasm: Hsp70-Bag3 module regulates HRI-dependent phosphorylation of eIF2α

S. Patel, S. Kumar, A. Hesin, J. Yaglom, M. Y. Sherman

The paper shows that JG-98, an Hsp70 inhibitor, causes cell death by activating the eIF2α phosphorylation pathway through the Hsp70-Bag3 complex, linking ER and cytoplasmic proteotoxicity.

bioRxiv · Apr 13, 2021Cell Biology