Author

I. Bayles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

C. F. Bartels· 2 shared E. S. Hong· 2 shared P. C. Scacheri· 2 shared W. D. Pontius· 2 shared A. R. Morton· 1 shared A. Saiakhova· 1 shared C. Peacock· 1 shared D. N. Wald· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

C. F. Bartels

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Author profile →

2 papers

Recent·Most cited

Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis

W. D. Pontius, E. S. Hong, Z. J. Faber, J. Gray, C. Peacock, I. Bayles, K. Lovrenert, C. F. Bartels, P. C. Scacheri

This study identifies dynamic chromatin accessibility changes during osteosarcoma metastasis to the lung, revealing epigenetic states critical for metastatic colonization and new therapeutic targets.

Nature Communications · Nov 8, 2023Peer-reviewedCancer Biology

Mismatch-repair signature mutations activate gene enhancers across colorectal cancer epigenomes

S. Hung, A. Saiakhova, Z. Faber, C. F. Bartels, D. Neu, I. Bayles, E. Ojo, E. S. Hong, W. D. Pontius, A. R. Morton, R. Liu, M. F. Kalady, D. N. Wald, S. Markowitz, P. C. Scacheri

The paper identifies MMR signature mutations in colorectal cancer that activate enhancers by increasing FOX factor affinity and promoting tumor growth.

bioRxiv · Sep 7, 2018Cancer Biology