Author

I. D. Pogozheva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

M. Raghavan· 2 shared A. Bhide· 1 shared A. Lomize· 1 shared A. Venkatesan· 1 shared J. Geng· 1 shared M. Kandarpa· 1 shared M. Talpaz· 1 shared S. Cherepanov· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

M. Raghavan

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Author profile →

2 papers

Recent·Most cited

Structural modeling of cytokine-receptor-JAK2 signaling complexes using AlphaFold Multimer

I. D. Pogozheva, S. Cherepanov, S.-J. Park, M. Raghavan, W. Im, A. Lomize

The paper uses AlphaFold Multimer to model cytokine-receptor-JAK2 signaling complexes, revealing activation mechanisms and oncogenic mutation impacts.

bioRxiv · Jun 14, 2023 · PreprintBiochemistry

Mpl is activated by dimers of MPN-linked calreticulin mutants stabilized by disulfide bonds and ionic interactions

A. Venkatesan, J. Geng, M. Kandarpa, S. Wijeyesakere, A. Bhide, M. Talpaz, I. D. Pogozheva, M. Raghavan

This study identifies how mutated calreticulin (CRTDel52) forms dimers stabilized by disulfide bonds and ionic interactions, leading to Mpl activation and cytokine-independent cell proliferation in MPNs.

bioRxiv · Sep 13, 2020 · PreprintCancer Biology