Cancer BiologybioRxivPreprint
Mpl is activated by dimers of MPN-linked calreticulin mutants stabilized by disulfide bonds and ionic interactions
A. Venkatesan, J. Geng, M. Kandarpa…·M. Raghavan
This study identifies how mutated calreticulin (CRTDel52) forms dimers stabilized by disulfide bonds and ionic interactions, leading to Mpl activation and cytokine-independent cell proliferation in MPNs.
DOI 10.1101/2020.09.13.295485