Author

I. J. Groves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

N. Coleman· 2 shared A. J. Enright· 1 shared A. Szymula· 1 shared B. S. Holder· 1 shared C. G. Scarpini· 1 shared C. M. O'Connor· 1 shared C. Varnai· 1 shared E. L. Drane· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

N. Coleman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Host-encoded CTCF regulates human cytomegalovirus latency via chromatin looping

I. J. Groves, C. M. O'Connor

This study shows CTCF binding to the HCMV MIE locus maintains latency by enabling chromatin looping that represses transcription, which is lost during reactivation.

bioRxiv · Sep 18, 2023Microbiology

CTCF association with episomal HPV16 genomes regulates viral oncogene transcription and splicing

I. J. Groves, G. Tang, I. Pentland, J. L. Parish, N. Coleman

This study shows CTCF binds to HPV16 episomes, regulating oncogene transcription and splicing during viral lifecycle, with CTCF playing a greater role than SMC1A in viral gene expression and genome maintenance.

bioRxiv · Feb 18, 2021 · PreprintCancer Biology

Three-dimensional interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis

I. J. Groves, E. L. Drane, M. Michalski, J. M. Monahan, C. G. Scarpini, S. P. Smith, G. Bussotti, C. Varnai, S. Schoenfelder, P. Fraser, A. J. Enright, N. Coleman

This study shows HPV integration disrupts host gene expression by altering 3D chromatin interactions, revealing a mechanism for early cervical cancer development.

bioRxiv · Feb 3, 2021Cancer Biology

Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naive B cells, and facilitates recruitment of transcription factors to the viral genome.

A. Szymula, R. D. Palermo, I. J. Groves, M. Ba abdullah, B. S. Holder, R. E. White

This paper shows EBNA-LP is essential for transforming naive B cells and facilitates transcription factor recruitment to the viral genome, with distinct effects on different B cell subsets.

bioRxiv · Aug 22, 2017Microbiology