Author

N. Coleman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 7

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

I. J. Groves· 2 shared M. A. Sanders· 2 shared M. D. Young· 2 shared P. J. Campbell· 2 shared T. H. H. Coorens· 2 shared T. J. Mitchell· 2 shared A. Abaurrea· 1 shared A. Cagan· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

I. J. Groves

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7 papers

Recent·Most cited

The Children's Brain Tumor Network (CBTN) - Accelerating Research in Pediatric Central Nervous System Tumors through Collaboration and Open Science

J. V. Lilly, J. L. Rokita, J. L. Mason, T. Patton, S. Stefankiewiz, D. Higgins, G. Trooskin, C. A. Larouci, K. Arya, E. Appert, A. P. Heath, Y. Zhu, M. A. Brown, B. Zhang, B. K. Farrow, , W. Rife

The paper describes the Children's Brain Tumor Network (CBTN), a consortium that collects and shares multi-omic data and biospecimens to advance research on pediatric brain tumors.

bioRxiv · Oct 14, 2022Cancer Biology

Clonal diversification and histogenesis of malignant germ cell tumours

T. R. W. Oliver, L. Chappell, R. Sanghvi, L. Deighton, N. Ansari-Pour, S. Dentro, M. D. Young, T. H. H. Coorens, H. Jung, T. M. Butler, M. D. C. Neville, D. Leongamornlert, M. A. Sanders, Y. Hooks, A. Cagan, , S. Behjati

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

bioRxiv · Feb 1, 2022Cancer Biology

CTCF association with episomal HPV16 genomes regulates viral oncogene transcription and splicing

I. J. Groves, G. Tang, I. Pentland, J. L. Parish, N. Coleman

This study shows CTCF binds to HPV16 episomes, regulating oncogene transcription and splicing during viral lifecycle, with CTCF playing a greater role than SMC1A in viral gene expression and genome maintenance.

bioRxiv · Feb 18, 2021 · PreprintCancer Biology

Three-dimensional interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis

I. J. Groves, E. L. Drane, M. Michalski, J. M. Monahan, C. G. Scarpini, S. P. Smith, G. Bussotti, C. Varnai, S. Schoenfelder, P. Fraser, A. J. Enright, N. Coleman

This study shows HPV integration disrupts host gene expression by altering 3D chromatin interactions, revealing a mechanism for early cervical cancer development.

bioRxiv · Feb 3, 2021Cancer Biology

Stromal Oncostatin M axis promotes breast cancer progression

A. M. Araujo, A. Abaurrea, P. Azcoaga, J. I. Lopez-Velazco, R. Rezola, I. Osorio-Querejeta, F. Valdes-Mora, J. M. Flores, L. Jenkins, P. Fernandez-Nogueira, N. Ferrari, N. Martin-Martin, A. Tzankov, S. Eppenberger-Castori, I. Alvarez-Lopez, , C. H. Lawrie

This study identifies the stromal OSM:OSMR axis as a key driver of breast cancer progression by reprogramming the tumor microenvironment.

bioRxiv · Oct 30, 2020Cancer Biology

Cellular mRNA signals in human kidney tumors

M. D. Young, T. J. Mitchell, L. M. Custers, T. Margaritis, F. Morales, K. Kwakwa, E. Khabirova, G. Kildisiute, T. R. Oliver, R. R. d. Krijger, M. M. v. d. Heuvel-Eibrink, F. Comitani, A. Piapi, E. B. Blanco, C. Thevanesan, , Holste

This study analyzes mRNA signals in 1,300 kidney tumors to determine their differentiation state and origin, finding that childhood tumors show fetal signals while most adult tumors do not, with exceptions in certain cancer types.

bioRxiv · Mar 19, 2020Cancer Biology

The landscape of somatic mutation in normal colorectal epithelial cells

H. Lee-Six, P. Ellis, R. J. Osborne, M. A. Sanders, L. Moore, N. Georgakopoulos, F. Torrente, A. Noorani, M. Goddard, P. Robinson, T. H. H. Coorens, L. O'Neill, C. Alder, J. Wang, R. C. Fitzgerald, , M. R. Stratton

This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.

bioRxiv · Sep 13, 2018Cancer Biology