Thermostability and binding properties of single-chained Fv fragments derived from therapeutic antibodies
T. Tadokoro, H. Tsuboi, K. Nakamura, T. Hayakawa, R. Ohmura, I. Kato, M. Inoue, S.-i. Tsunoda, S. Niizuma, Y. Okada, S. Otsuguro, K. Maenaka
This study evaluates the thermostability and binding properties of scFv fragments from FDA-approved antibodies, showing that stable scFvs maintain antigen binding.
bioRxiv · Feb 9, 2024Bioengineering