Y. Okada

Federated single-cell QTL meta-analysis reveals novel disease mechanisms

The paper performs a federated cis-eQTL meta-analysis across single-cell datasets to identify cell-type-specific genetic effects and link them to disease mechanisms.

The Rubicon-WIPI axis regulates exosome biogenesis during aging

This study identifies the Rubicon-WIPI axis as a regulator of exosome biogenesis, showing its role in age-dependent exosome release and microRNA fate in mice.

Theoretical insights into rotary mechanism of MotAB in the bacterial flagellar motor

This study uses computational modeling and molecular dynamics simulations to elucidate the proton-transfer coupled rotation mechanism of MotAB in bacterial flagellar motors.

Thermostability and binding properties of single-chained Fv fragments derived from therapeutic antibodies

This study evaluates the thermostability and binding properties of scFv fragments from FDA-approved antibodies, showing that stable scFvs maintain antigen binding.

StayGold Photostability under Different Illumination Modes

This study compares the photostability of StayGold with three other FPs under different illumination modes in microscopy, finding that StayGold maintains superior photostability in multi-beam LSCM but shows variable performance in single-beam LSCM.

HDAC1-3 inhibition reduces CCR2 expression and immunosuppressive function of myeloid-derived suppressor cells

This study shows HDAC1-3 inhibitors reduce CCR2 expression and immunosuppressive function of MDSCs, enhancing antitumor effects in HCC.

In situ Quantification of Biomolecular Concentration of Cytoplasmic Membraneless Organelles in a Living Cell

The paper quantifies biomolecular concentrations in stress granules of living cells under oxidative stress using near-IR fluorescence and Raman imaging.

A novel mouse allele of the DNA/RNA helicase senataxin (Setxspcar3) causing meiotic arrest of spermatocytes and male infertility

This study identifies a new Setx allele causing male infertility and female subfertility in mice by disrupting meiosis and spermatogenesis through R-loop accumulation and DNA damage.

Single-molecule tracking of Nanog and Oct4 in mouse embryonic stem cells

The paper tracks Nanog and Oct4 in mouse embryonic stem cells to study their roles in pluripotency, finding that Nanog interacts longer with targets during differentiation, suggesting a feedback mechanism.

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

This study develops a bulk differentiation method for MYOD1-hiPSCs to generate contractile skeletal muscles, improving efficiency and reducing clonal variation compared to clonal methods.

Cancer/Testis genes are predictive of breast tumor subtypes

The paper identifies HORMAD1 and CT83 as Cancer/Testis genes predictive of basal-like breast tumors and shows their epigenetic regulation and prognostic significance.

Live cell imaging of metabolic heterogeneity by quantitative fluorescent ATP indicator protein, QUEEN-37C.

The paper introduces QUEEN-37C, a fluorescent ATP indicator protein, enabling real-time, quantitative measurement of ATP concentration in living mammalian cells and revealing metabolic heterogeneity.

Compartmentalized three-dimensional human neuromuscular tissue models fabricated on a well-plate-format microdevice

This study develops a microdevice for compartmentalized coculturing of motor neurons and skeletal muscle tissues to form functional neuromuscular junctions and test drug responses.

Natural selection reverses the exaggeration of a male sexually selected trait, which increases female fitness.

The paper uses experimental evolution to show that male-specific predation reduces exaggerated male traits in beetles, indirectly increasing female fitness through genetic correlations.

Individual Ants Do Not Show Active/rest Rhythms in Natural Nest Conditions

This study shows that individual ants do not exhibit active/rest rhythms in natural nest conditions, but solitary ants do, suggesting social interactions suppress circadian rhythms in colonies.

Enhancer Remodeling Promotes Tumor-Initiating Activity in NRF2-Activated Non-Small Cell Lung Cancers

The paper identifies NRF2-CEBPB cooperativity in promoting tumor-initiating activity in NRF2-activated NSCLCs through enhancer remodeling and the NRF2-NOTCH3 regulatory axis.

NUDT21 links mitochondrial IPS-1 to RLR-containing stress granules and activates host antiviral defense

This study shows NUDT21 connects RLRs in stress granules to mitochondrial IPS-1, enabling antiviral defense by facilitating type I IFN induction.

Bipartite network analysis of ant-task associations reveals task groups and absence of colonial daily activity

The paper uses bipartite network analysis to study ant task allocation, identifying task groups and finding no daily rhythm in task execution.

Robust and Bright Genetically Encoded Fluorescent Markers for Highlighting Structures and Compartments in Mammalian Cells

Polyandry and paternity affect disease resistance in eusocial wasps - support for the pathogen parasite hypothesis

The paper tests the parasite-pathogen hypothesis in eusocial wasps by showing differential disease resistance among workers of different patrilines.

Reconstruction of Par polarity in apolar cells reveals a dynamic process of cortical polarization

The paper reconstructs Par polarity in non-polarized Drosophila cells and identifies dynamic steps in cortical polarization.

Dipeptidyl dipeptidase-4 inhibitor, MK-0626, promotes bone marrow-derived endothelial progenitor cell bioactivities for vascular regeneration in diet-induced obese mice

This study shows that MK-0626, a DPP-4 inhibitor, improves EPC bioactivity and reduces inflammation in diet-induced obese mice with ischemia.

Application of the fluctuation theorem for non-invasive force measurement in living neuronal axons

The paper applies the fluctuation theorem to measure non-invasive forces on endosomes in axonal transport, finding that single cargo vesicles are conveyed by one to three or four units of force.

Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis

This study shows peroxisomes regulate mitochondrial dynamics and apoptosis by affecting Drp1-mediated fission and caspase activation.

Second harmonic generation polarization microscopy as a tool for protein structure analysis

This paper demonstrates the use of SHG polarization microscopy to detect protein conformational changes in macromolecular assemblies without labeling.