M. Inoue

Generation of human-pig chimeric renal organoids using iPSC technology

This study generates human-pig chimeric renal organoids using modified human-mouse chimeric methods, demonstrating successful interspecies kidney development.

Thermostability and binding properties of single-chained Fv fragments derived from therapeutic antibodies

This study evaluates the thermostability and binding properties of scFv fragments from FDA-approved antibodies, showing that stable scFvs maintain antigen binding.

Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy

This study identifies biallelic LARS1 variants as a cause of infantile liver failure by showing they induce steatosis via enhanced autophagy in zebrafish.

Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport

This study determines the cryo-EM structure of full-length ERGIC-53 complexed with MCFD2, revealing its tetrameric architecture and mechanism of cargo transport.

Ultra-Rapid and Specific Gelation of Collagen Molecules for Transparent and Tough Gels by Transition Metal Complexation

This paper develops a method to rapidly form transparent and tough collagen gels using transition metal complexation, enabling deep-live cell observation in a mechanically tunable environment.

Butyrate, valerate, and niacin ameliorate anaphylaxis by suppressing IgE-dependent mast cell activation: Roles of GPR109A, PGE2, and epigenetic regulation

This study shows that butyrate and valerate reduce IgE-mediated mast cell activation by enhancing PGE2 release and GPR109A signaling, while niacin also alleviates anaphylaxis through similar mechanisms.

Isolation and genomic and physiological characterization of Parageobacillus sp. G301, the isolate capable of both hydrogenogenic and aerobic carbon monoxide oxidation

This paper isolates and characterizes Parageobacillus sp. G301, a novel CO oxidizer capable of both hydrogenogenic and aerobic CO oxidation using both Ni-CODH and Mo-CODH.

Inhibition of the BMP pathway suppresses tumor growth via downregulation of EGFR in MEK/ERK-dependent colorectal cancer

This study shows that inhibiting the BMP pathway suppresses colorectal cancer growth by reducing EGFR, and combining BMP and MEK inhibition enhances therapeutic effects in patient-derived organoids.

Structural basis for ion selectivity in potassium-selective channelrhodopsins

The paper determines the cryo-EM structures of two K+-selective channelrhodopsins, revealing a unique mechanism for K+ selectivity distinct from canonical K+ channels.

Hepatocyte Differentiation From Mouse Liver Ductal Organoids By Transducing Four Liver-Specific Transcription Factors

This study identifies four transcription factors that enhance hepatocyte differentiation from liver ductal organoids, improving their functionality and reducing cholangiocyte characteristics.

Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions

This study uses indirect CRISPR screening with photoconversion to identify key factors of drug resistance mediated by cell-cell interactions, finding genes that reduce cancer cell apoptosis when knocked out in supporting cells.

Distinct and interchangeable growing patterns in colorectal cancer stem-like cells are regulated by Musashi-1

The paper identifies distinct growth patterns in colorectal cancer stem-like cells and shows Musashi-1 regulates their plasticity and drug resistance.

Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts

The paper demonstrates that liver ductal organoids can reconstruct intrahepatic bile ducts in decellularized liver grafts, mimicking native liver structure and function.

AIM2 inflammasome activation in astrocytes occurs during the late phase of EAE

This study identifies AIM2 inflammasome activation in astrocytes during the late phase of EAE, distinct from traditional inflammasome-mediated inflammation.

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

Seroepidemiological survey on pigs and cattle for novel K88 (F4)-like colonization factor detected in human enterotoxigenic Escherichia coli

The paper reports antibodies in pigs and cattle against a novel K88-like colonization factor from human ETEC, suggesting zoonotic potential and the need for One Health approaches.

Entangled gene regulatory networks with cooperative expression endow robust adaptive responses to unforeseen environmental changes

The paper shows complex gene regulatory networks with cooperative expression enable robust and adaptive responses to unforeseen environmental changes through global gene expression correlations.

Genetics of mouse Tas1r3-independent sucrose intake

This study identifies two new QTLs, Scon3 and Scon4, that influence sucrose intake in mice and act through a common postoral mechanism.

Genetics of mouse behavioral and peripheral neural responses to sucrose

This study identifies QTLs for sucrose consumption and neural responses in mice, finding new loci and confirming a known one involving the Tas1r3 gene.

Lysosomal microautophagic pathway links proteostasis to protein aggregation disease

This study identifies SIDT2 as a mediator of microautophagy that delivers cytosolic proteins into lysosomes, linking proteostasis to protein aggregation disease.

Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway

This study shows Dectin-1 protects against CNS autoimmunity through a non-canonical pathway independent of Card9, promoting neuroprotective molecules like Osm in myeloid cells and reducing EAE severity via astrocytic OsmR signaling.

Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail

Cryo-EM structures of SERCA2b reveal how the luminal extension tail regulates its activity by controlling conformational transitions between states.

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

This study shows that albumin oxidation causes redox imbalance, leading to inflammation-independent NETosis and lung-specific cancer metastasis.