Author

I. Lei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

L. Liu· 4 shared S. Tian· 4 shared W. Gao· 4 shared Y. Guo· 4 shared Z. WangiD· 3 shared E. Chen· 2 shared S. Wang· 2 shared Z. Li· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCell Biology

L. Liu

Mutual co-authors in cluster

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4 papers

Recent·Most cited

14-3-3 binding motif phosphorylation disrupts Hdac4 organized condensates to stimulate cardiacreprogramming

L. Liu, I. Lei, S. Tian, W. Gao, Y. Guo, Z. Li, Z. Sabry, P. Tang, E. Chen, Z. Wang

This study identifies a phosphorylation code in 14-3-3 binding motifs that stimulates induced cardiomyocyte formation by disrupting Hdac4 condensates.

Cell Reports · Apr 1, 2024Peer-reviewedCell Biology

Transient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway

L. Liu, Y. Guo, S. Tian, I. Lei, W. Gao, Z. Li, S. Wang, E. Chen, Z. Wang

This study identifies BRD4 degradation as a method to enhance cardiac reprogramming by inhibiting the JAK/STAT pathway activated by macrophages and oncostatin M.

bioRxiv · Dec 31, 2023 · PreprintCell Biology

Acetyl-CoA production by select metabolic pathways promotes cardiac repair after myocardial infarction via mediating histone acetylation

I. Lei, S. Tian, W. Gao, L. Liu, Y. Guo, Z. Wang

This study shows that acetyl-CoA from specific metabolic pathways enhances cardiac repair after myocardial infarction by promoting histone acetylation and antioxidant gene expression.

bioRxiv · Dec 24, 2019Cell Biology

Enhancing Cardiac Reprogramming by Suppressing Specific C-C Chemokine Signaling Pathways

Y. Guo, I. Lei, S. Tian, W. Gao, K. Hacer, Y. Li, S. Wang, L. Liu, Z. Wang

The paper identifies a chemical combination (IMAP) that enhances cardiac reprogramming by suppressing specific C-C chemokine signaling pathways.

bioRxiv · Jan 16, 2019 · PreprintCell Biology