P. Tang

14-3-3 binding motif phosphorylation disrupts Hdac4 organized condensates to stimulate cardiacreprogramming

This study identifies a phosphorylation code in 14-3-3 binding motifs that stimulates induced cardiomyocyte formation by disrupting Hdac4 condensates.

Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in ferrets

This study shows that probiotic consortia reduce SARS-CoV-2 viral load and enhance anti-viral immunity in ferrets and human immune cells.

Inositol lipid synthesis is widespread in host-associated Bacteroidetes

This study identifies two pathways for inositol lipid synthesis in host-associated Bacteroidetes, showing their prevalence and potential role in host interactions.

CARD8 inflammasome mediates pyroptosis of HIV-1-infected cells by sensing viral protease activity

This study identifies CARD8 as a sensor of HIV-1 protease activity, triggering pyroptosis of infected cells and clearing latent HIV-1 in CD4+ T cells.

Virome-wide serological profiling reveals association of herpesviruses with obesity

This study uses ViScan to find HSV-1 and Rhinovirus A associations with obesity in Qatari adults, but not children.

Metformin chlorination byproducts in drinking water exhibit marked toxicity to nematode worms, human cells, and mice

This study shows that metformin chlorination byproducts are toxic to nematodes, human cells, and mice, and identifies boiling and activated carbon as effective removal methods.

An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy.

This paper develops an inducible mouse model of childhood HIV-associated nephropathy (HIVAN) and shows HIV-Tat contributes to the disease when combined with other HIV-1 genes and heparin-binding cytokines.

Accurate Diagnosis of Colorectal Cancer Based on Histopathology Images Using Artificial Intelligence

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

A Metagenomics - Based Diagnostic Approach for Central Nervous System Infections in Hospital Acute Care Setting

This study develops a metagenomics-based diagnostic approach for CNS infections using mNGS, showing 95% accuracy in detecting pathogens in CSF samples compared to conventional methods.

Microbial community dynamics of surface water in British Columbia, Canada

The paper compares methods for measuring E. coli in two watersheds, finding variability in results and suggesting alternative microbial indicators for fecal contamination.

A novel real-time PCR assay panel for detection of common respiratory pathogens in a convenient, strip-tube array format

The paper develops and validates a real-time PCR assay (Respanel) for detecting respiratory pathogens, showing higher sensitivity than Resplex and comparable performance to FTDRP21.