Loss of the H4 lysine methyltransferase KMT5B drives tumorigenic phenotypes by depleting H3K27me3 at loci otherwise retained in H3K27M mutant DIPG cells
K. Kessler, A. Mackay, Y. Grabovska, V. Molinari, A. Burford, S. Temelso, H. Tari, E. Yara-Romero, I. Liu, L. Yu, D. Castel, J. Choudhary, A. Sottoriva, M. Filbin, M. Vinci, C. Jones
The paper shows that loss of KMT5B in DIPG cells depletes retained H3K27me3 loci, leading to transcriptional changes that promote tumorigenesis.
bioRxiv · Jul 19, 2021 · PreprintCancer Biology