J. Choudhary

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.

This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.

Spatial control of the APC/C ensures the rapid degradation of Cyclin B1

The paper shows that spatial regulation of the APC/C at mitotic chromosomes enables rapid Cyclin B1 degradation, ensuring proper cell division and genomic stability.

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

Multifactorial remodeling of the cancer immunopeptidome by interferon gamma

This study identifies factors influencing immunopeptidome remodeling by IFN-gamma in colorectal cancer, revealing proline's role in peptide downregulation on HLA-I.

Transcriptome-wide identification of coding and noncoding RNA-binding proteins defines the comprehensive RNA interactome of Leishmania mexicana

This study identifies 2,417 RNA-binding proteins in Leishmania mexicana, including novel non-poly(A)-RNA-binding proteins, and reveals their roles in RNA-protein interactions and regulation of the protein kinome.

Loss of the H4 lysine methyltransferase KMT5B drives tumorigenic phenotypes by depleting H3K27me3 at loci otherwise retained in H3K27M mutant DIPG cells

The paper shows that loss of KMT5B in DIPG cells depletes retained H3K27me3 loci, leading to transcriptional changes that promote tumorigenesis.

The midbody interactome reveals new unexpected roles for PP1 phosphatases in cytokinesis

The paper characterizes the midbody interactome, revealing PP1 phosphatases regulate microtubule dynamics and centralspindlin complex function during cytokinesis.

Sub-minute phosphoregulation of cell-cycle systems during Plasmodium gamete formation

This study identifies phosphoregulation networks during Plasmodium gamete formation using high-resolution phosphoproteomics.