I. M. Tolic

Microtubule poleward flux as a target for modifying chromosome segregation errors

This study shows that reducing microtubule poleward flux can rescue chromosome segregation errors in cancer cells by slowing kinetochore microtubule growth and improving alignment.

CENP-E initiates chromosome congression by opposing Aurora kinases to promote end-on attachments

This study shows CENP-E initiates chromosome congression by stabilizing end-on attachments and counteracting Aurora B phosphorylation, promoting biorientation-dependent movement.

Life cycle-coupled evolution of mitosis in close relatives of animals

The paper investigates mitotic strategies in Ichthyosporea, showing divergence towards fungal-like closed or animal-like open mitosis, with multinucleated life cycles favoring closed mitosis.

Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation, and chromosome segregation of sexual transmission stages

Coordinated poleward flux of sister kinetochore fibers drives chromosome alignment

The paper introduces a flux-driven model for chromosome alignment, showing that length-dependent kinetochore fiber flux, regulated by Kif18A, Kif4A, and NuMA, promotes proper chromosome positioning.

Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes

This paper introduces a mathematical model to explain how proliferative advantage of specific aneuploid cells drives tumor karyotype evolution through chromosome gains and losses.

Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

The paper shows that kinetochores and chromosomes drive the formation of microtubule bundles during spindle assembly through a network-to-bundles transition.

Naegleria's mitotic spindles are built from unique tubulins and highlight core spindle features

The paper identifies unique mitotic tubulins in Naegleria amoebae and characterizes their spindle structure, suggesting ancestral features of mitosis.

Measurement of curvature and twist of microtubule bundles in the mitotic spindle

This paper introduces a method to measure curvature and twist of microtubule bundles in mitotic spindles using confocal microscopy and geometric analysis.

The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin

This study measures spindle chirality and shows it is regulated by microtubule motors and augmin, with implications for mechanical response to forces during mitosis.

Augmin prevents merotelic attachments by promoting proper arrangement of bridging and kinetochore fibers

This paper shows that augmin promotes proper microtubule arrangement to prevent merotelic attachments during mitosis.

Optogenetic control of PRC1 reveals that bridging fibers promote chromosome alignment by overlap length-dependent forces

This study uses optogenetic removal of PRC1 to show that bridging fibers promote chromosome alignment through overlap length-dependent forces.

Chromosome segregation is driven by joint microtubule sliding action of kinesins KIF4A and EG5

The paper identifies KIF4A and EG5 as essential for spindle elongation through microtubule sliding in human cells, showing two independent sliding modules drive this process.

Pivoting of microtubules driven by minus end directed motors leads to their alignment to form an interpolar bundle

The paper shows microtubules from opposite poles align into antiparallel bundles through random rotation and minus end directed motor activity.

The mitotic spindle is chiral due to torques generated by motor proteins

The paper shows that the mitotic spindle is chiral due to torques from motor proteins, demonstrated through microscopy and a theoretical model.