R. Tewari

Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation

This study identifies NEK1's role in organizing the MTOC and ensuring kinetochore attachment during rapid mitosis in Plasmodium male gamete formation.

Atypical flagella assembly and haploid genome coiling during male gamete formation in Plasmodium

This study uses electron microscopy to reveal the 3D organization of axonemes and genome coiling during male gamete formation in Plasmodium berghei.

Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation, and chromosome segregation of sexual transmission stages

Dynamic S-acylation of STIM1 is required for store-operated Ca 2+ entry

The paper shows that S-acylation of STIM1 is required for CRAC channel assembly and function during store-operated calcium entry.

Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission

This study investigates the molecular mechanism of Plasmodium kinesin-8B, showing its role in male gamete development and parasite transmission through ATP-dependent microtubule interactions and structural adaptations.

Plasmodium SAS4/CPAP is a flagellum basal body component during male gametogenesis but is not essential for parasite transmission

This study investigates the role of SAS4/CPAP in Plasmodium male gametogenesis, showing it is part of the basal body but not essential for gamete formation or parasite transmission.

Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle

The paper identifies key kinesins involved in the malaria parasite life cycle in mammalian and mosquito hosts, showing kinesin-13 is essential for growth in mammals while others are critical for mosquito transmission.

Molecular mechanism of a parasite kinesin motor and implications for its inhibition

This study characterizes the molecular mechanism of Plasmodium falciparum kinesin-5 (PfK5) and identifies structural features that could enable selective inhibition of this parasite's motor.

Protein Phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages

The paper investigates the role of Protein Phosphatase 1 (PP1) in atypical mitotic and meiotic divisions during Plasmodium sexual stages, suggesting PP1 inhibitors could block parasite transmission.

Calcium-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells

This study identifies DHHC21 as a calcium/calmodulin-dependent enzyme critical for CD4+ T cell activation and differentiation through S-acylation of signaling proteins.

MRE11 is crucial for malaria transmission and its absence affects expression of interconnected networks of key genes essential for life

This study shows that MRE11 is essential for Plasmodium development in mosquitoes, with its absence causing transcriptional changes in critical biological processes and blocking parasite transmission.

Plasmodium berghei kinesin-5 associates with the spindle apparatus during cell division and is important for efficient production of infectious sporozoites

This study identifies kinesin-5's role in Plasmodium berghei cell division, showing it is essential for sporozoite production and associated with the spindle apparatus.

Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission

This study identifies DEH as an ER-localized protein essential for oocyst mitotic division in Plasmodium berghei, disrupting sporogony and parasite transmission.

T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells

This study identifies S-acylation of ZAP-70 as a T cell receptor-dependent post-translational modification essential for T cell signaling and activation.

Conservation of the Toxoplasma conoid complex proteome reveals a cryptic conoid in Plasmodium that differentiates between blood- and vector-stage zoites

The paper uses spatial proteomics and microscopy to show the conoid is conserved across apicomplexans, including Plasmodium, with structural differences between blood and vector stages.

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of Plasmodium berghei during gametogony and parasite transmission.

This study identifies CRK5 as a critical regulator of atypical DNA replication in Plasmodium berghei during gametogony and mosquito transmission.

Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation

The paper studies the dynamics of the NDC80 complex in Plasmodium berghei to reveal unique chromosome segregation mechanisms during parasite proliferation.

Regulation of T cell receptor signaling by protein acyltransferase DHHC21

This study identifies DHHC21 as a critical regulator of T cell receptor signaling through S-acylation, showing its role in T cell activation and differentiation.

Plasmodium condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission

Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission

This study identifies kinesin-8B's role in malaria parasite flagellum formation and transmission by analyzing its localization and function during gamete development.

Plasmodium Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission

This study identifies Plasmodium Kinesin-8X as essential for endomitotic division during oocyst development and parasite transmission.

Systematic analysis of Plasmodium myosins reveals differential expression, localization and function in invasive and proliferative parasite stages

This study systematically analyzes Plasmodium myosins, revealing their differential expression, localization, and functional roles in invasive and proliferative parasite stages.