Author

K. G. Le Roch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Cell Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:chromatin & epigenetic regulation· 7 Research Focus:cell type annotation· 6 Research Focus:gene regulatory network inference· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Organism:plant (other)· 4 Research Focus:drug response / drug discovery· 3

Frequent Co-Authors

S. Abel· 13 shared A. A. Holder· 6 shared D. Brady· 6 shared M. Zeeshan· 6 shared R. Tewari· 6 shared D. J. P. Ferguson· 4 shared E. Daniel· 4 shared E. Rea· 4 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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13 shared papersMicrobiology

S. Abel

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Author profile →

13 papers

Recent·Most cited

Multiomics analysis reveals B. MO1 as a distinct Babesia species and provides insights into its evolution and virulence.

P. Singh, P. Vydyam, T. Fang, M. Kumar, K. Estrada, R. Grande, A. Sanchez-Flores, L. M. Gonzalez, E. Montero, S. Chakravarty, S. Lonardi, V. Berry, V. Ranwez, B. Carcy, D. Depoix, , C. Ben Mamoun

The paper identifies B. MO1 as a distinct Babesia species through multiomics analysis, revealing genomic and functional differences from B. divergens and insights into their evolution and virulence.

Emerging Microbes & Infections · Sep 1, 2024Peer-reviewedMicrobiology

Toxoplasma gondii F-Box Protein L2 Silences Feline-Restricted Genes Necessary for Sexual Commitment

C. G. Baptista, S. Hosking, E. Gas-Pascual, L. Ciampossine, S. Abel, M.-A. Hakimi, V. Jeffers, K. G. Le Roch, C. M. West, I. Blader

This paper identifies TgFBXL2, an F-box protein in Toxoplasma gondii, which represses feline-restricted genes required for sexual commitment by modulating SCF-E3 ubiquitin ligase activity.

bioRxiv · Dec 18, 2023 · PreprintMicrobiology

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

Z. M. Chahine, S. Abel, T. Hollin, J. H. Chung, G. L. Barnes, M. E. Daub, I. Renard, J. Y. Choi, P. Vydyam, A. Chattopadhyay Pal, M. Argomaniz, C. Banks, J. kirkwood, A. Saraf, I. Camino Diaz, , K. G. Le Roch

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

bioRxiv · Nov 21, 2023 · PreprintMicrobiology

PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

Z. M. Chahine, M. Gupta, T. Lenz, T. Hollin, S. Abel, C. Banks, A. Saraf, J. Prudhomme, S. Bhanvadia, L. Florens, K. G. Le Roch

This study shows PfMORC regulates chromatin structure and gene repression in Plasmodium falciparum, essential for parasite survival and a potential target for antimalarial drugs.

bioRxiv · Sep 11, 2023Microbiology

Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation, and chromosome segregation of sexual transmission stages

M. Zeeshan, E. Rea, S. Abel, K. Vukusic, R. Markus, D. Brady, A. A. Eze, R. Rashpa, A. Balestra, A. Bottrill, M. Brochet, D. Guttery, I. M. Tolic, A. A. Holder, K. G. Le Roch, , R. Tewari

bioRxiv · Jan 29, 2023 · PreprintCell Biology

Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite.

G. Batugedara, X. M. Lu, S. Abel, Z. Chahine, B. Hristov, D. Williams, T. Hollin, T. Wang, A. Cort, T. Lenz, T. Thompson, J. Prudhomme, A. K. Tripathi, G. Xu, J. Cudini, , K. G. Le Roch

This study identifies and characterizes long non-coding RNAs (lncRNAs) in Plasmodium falciparum, revealing their role in gene regulation, pathogenicity, and sexual differentiation.

bioRxiv · Oct 12, 2022 · PreprintMicrobiology

Decoding The Nuclear Genome of The Human Pathogen Babesia duncani Shed Light on its Virulence, Drug Susceptibility and Evolution among Apicomplexa

S. Lonardi, P. Singh, Q. Liang, P. Vydyam, E. Khabirova, T. Fang, S. Gihaz, J. Thekkiniath, M. Munshi, S. Abel, G. Batugedara, M. Gupta, X. M. Lu, T. Lenz, S. Chakravarty, , C. Ben Mamoun

This study decodes the nuclear genome of Babesia duncani, identifies virulence factors and drug targets, and discovers potent inhibitors for treating babesiosis.

bioRxiv · May 9, 2022Microbiology

Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle

M. Zeeshan, R. Rashpa, D. J. P. Ferguson, S. Abel, Z. Chahine, D. Brady, s. vaughan, C. A. Moores, K. G. Le Roch, M. Brochet, A. A. Holder, R. Tewari

The paper identifies key kinesins involved in the malaria parasite life cycle in mammalian and mosquito hosts, showing kinesin-13 is essential for growth in mammals while others are critical for mosquito transmission.

bioRxiv · May 26, 2021Cell Biology

The essential transcriptional regulator HDP1 drives expansion of the inner membrane complex during early sexual differentiation of malaria parasites.

R. Campelo Morillo, X. Tong, W. Xie, S. Abel, L. M. Orchard, W. Daher, D. Patel, W. S. Noble, K. G. Le Roch, B. F. C. Kafsack

This study identifies HDP1 as a transcriptional regulator essential for upregulating inner membrane complex genes during early gametocytogenesis in Plasmodium falciparum.

bioRxiv · Oct 26, 2020 · PreprintMicrobiology

Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation

M. Zeeshan, R. Pandey, D. J. P. Ferguson, E. C. Tromer, R. Markus, S. Abel, D. Brady, E. Daniel, R. R. Stanway, A. R. Bottrill, K. G. Le Roch, A. A. Holder, R. F. Waller, D. S. Guttery, R. Tewari

The paper studies the dynamics of the NDC80 complex in Plasmodium berghei to reveal unique chromosome segregation mechanisms during parasite proliferation.

bioRxiv · May 12, 2020Cell Biology

Plasmodium condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission

R. Pandey, S. Abel, M. Boucher, R. J. Wall, M. Zeeshan, E. Rea, A. Freville, X. M. Lu, D. Brady, E. Daniel, R. R. Stanway, S. Wheatley, G. Batugedara, T. Hollin, A. R. Bottrill, , R. Tewari

bioRxiv · Dec 22, 2019Cell Biology

Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission

M. Zeeshan, D. J. P. Ferguson, S. Abel, A. Burrrell, E. Rea, D. Brady, E. Daniel, M. Delves, S. Vaughan, A. A. Holder, K. G. Le Roch, C. A. Moores, R. Tewari

This study identifies kinesin-8B's role in malaria parasite flagellum formation and transmission by analyzing its localization and function during gamete development.

bioRxiv · Jul 2, 2019Cell Biology

Plasmodium Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission

M. Zeeshan, F. Shilliday, T. Liu, S. Abel, T. Mourier, D. J. P. Ferguson, E. Rea, R. R. Stanway, M. Roques, D. Williams, E. Daniel, D. Brady, A. J. Roberts, A. A. Holder, A. Pain, , R. Tewari

This study identifies Plasmodium Kinesin-8X as essential for endomitotic division during oocyst development and parasite transmission.

bioRxiv · Jun 29, 2019Cell Biology