Author

I. Manolaridis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

D. Ni· 2 shared H. Stahlberg· 2 shared J. Kowal· 2 shared K. P. Locher· 2 shared Q. Yu· 1 shared S. Jackson· 1 shared S. M. Jackson· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

D. Ni

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structures of ABCG2 under turnover conditions reveal a key step in drug transport mechanism

Q. Yu, D. Ni, J. Kowal, I. Manolaridis, S. M. Jackson, H. Stahlberg, K. P. Locher

This study presents cryo-EM structures of ABCG2 under turnover conditions, revealing conformational changes that elucidate the transport mechanism and substrate specificity.

bioRxiv · Mar 3, 2021Biophysics

Structural basis of drug recognition by the multidrug transporter ABCG2

J. Kowal, D. Ni, S. Jackson, I. Manolaridis, H. Stahlberg, K. P. Locher

This study presents cryo-EM structures of ABCG2 bound to anticancer drugs, revealing how it recognizes and binds exogenous compounds and the structural basis for drug-induced ATPase activity.

bioRxiv · Feb 18, 2021Biophysics