D. Ni

High fat low carbohydrate diet is linked to protection against CNS autoimmunity

This study links a high fat low carbohydrate diet to protection against CNS autoimmunity by showing reduced neuroinflammation and immunometabolic changes in a mouse model.

Arrestin recognizes GPCRs independently of the receptor state

This study shows arrestin2 binds to the β1-adrenergic receptor independently of receptor conformation or ligand type, driven by a conformational change in arrestin induced by a phosphopeptide.

The maternal and fetal metabolic and immune landscapes of gestational diabetes mellitus

This study analyzes transcriptomic data to explore how gestational diabetes mellitus affects maternal and fetal metabolic and immune landscapes.

Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4

The paper identifies the binding site of small molecule inhibitors NBA and IBA in TRPM4 using cryo-EM and patch clamp experiments.

Breastfeeding enhances intestinal gluconeogenesis in infants

This study reanalyzes microarray data to show breastfeeding enhances intestinal gluconeogenesis in infants, similar to observations in other mammals.

A unique human cord blood CD8+CD45RA+CD27+CD161+ T cell subset identified by flow cytometric data analysis using Seurat

Structure of a membrane-bound menaquinol:organohalide oxidoreductase

The paper presents the first cryo-EM structure of a functional menaquinol:organohalide oxidoreductase from Desulfitobacterium hafniense, revealing its mechanism of electron transfer and energy conservation during organohalide respiration.

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

The paper reports cryo-EM structures of mouse ACE2 bound to SARS-CoV-2 VOC Spike proteins, showing mutations enabling immune escape may expand host range.

De novo design of site-specific protein interactions with learned surface fingerprints

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties

This paper identifies a potent human monoclonal antibody, P2G3, that neutralizes multiple SARS-CoV-2 variants including Omicron, and demonstrates its protective efficacy in a monkey model.

Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion.

The paper reports cryo-EM structures of mouse ACE2 bound to Spike proteins of four SARS-CoV-2 variants, revealing mutations that enhance binding and immune evasion.

Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies

The paper uses cryo-EM to determine structures of the LptDE transporter complex with Pro-Macrobodies, revealing partially and fully opened states of the transporter during LPS translocation.

Structures of ABCG2 under turnover conditions reveal a key step in drug transport mechanism

This study presents cryo-EM structures of ABCG2 under turnover conditions, revealing conformational changes that elucidate the transport mechanism and substrate specificity.

Structural basis of drug recognition by the multidrug transporter ABCG2

This study presents cryo-EM structures of ABCG2 bound to anticancer drugs, revealing how it recognizes and binds exogenous compounds and the structural basis for drug-induced ATPase activity.

Dietary protein increases T cell independent sIgA production through changes in gut microbiota-derived extracellular vesicles

The paper shows dietary protein increases sIgA via gut microbiota-derived extracellular vesicles, independent of T cell pathways or microbiota composition.

Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein

This study uses cryo-EM to show that hACE2 binding causes SARS-CoV-2 Spike trimer disassembly and S1 domain rearrangement, suggesting a mechanism for soluble hACE2's therapeutic effect.