I. Mathieson

Predicting functional consequences of recent natural selection in Britain

This study predicts the functional consequences of recent natural selection in Britain by analyzing gene expression changes over 4500 years using ancient and present-day DNA data.

Hunter-gatherer admixture facilitated natural selection in Neolithic European farmers

The paper analyzes ancient DNA from Neolithic Europe to identify genomic regions affected by admixture and natural selection, finding evidence of selection on pigmentation and immune-related genes.

Direct detection of natural selection in Bronze Age Britain

The paper develops a method to estimate time-varying selection coefficients from ancient DNA data and identifies loci related to vitamin D and calcium in Bronze Age Britain.

Predicting skeletal stature using ancient DNA

This paper uses polygenic scores to predict femur length in ancient individuals, finding they explain 6.8% of variance, with sex explaining 15% and environmental factors also contributing.

The evolution of skin pigmentation associated variation in West Eurasia

This study investigates the role of directional selection in shaping skin pigmentation variation in ancient West Eurasians using ancient DNA and UK Biobank data, finding that selection primarily acted on a small number of large-effect variants.

Limited evidence for selection at the FADS locus in Native American populations

The paper shows that signals of selection at the FADS locus in Native American populations are confounded by recent adaptations in European and East Asian populations.

Neolithic genomes reveal a distinct ancient HLA allele pool and population transformation in Europe

The paper analyzes Neolithic genomes from Germany to show genetic heterogeneity and a high hunter-gatherer ancestry component in a WBC population, with distinct HLA allele pools related to viral immunity.

Genetic contributions to variation in human stature in prehistoric Europe

This study compares genetic and skeletal height changes in prehistoric Europe over 38,000 years, showing genetic predictions align with skeletal data in most periods but not all.

Tracking human population structure through time from whole genome sequences

This paper introduces MSMC-IM, a method to track human population structure through time using whole genome sequences, revealing deep ancestry in some African populations.

FADS1 and the timing of human adaptation to agriculture

The paper examines the association between FADS1 genetic variation and agricultural adaptation, finding no strong selection during the Neolithic transition but suggesting later environmental or demographic factors drove adaptation.

Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies

The paper shows that polygenic adaptation signals for height are overestimated due to uncorrected population structure in GWAS data.