Author

N. Patterson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:whole-genome sequencing· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:variant effect prediction· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Ganna· 2 shared C. Y. Chabu· 2 shared P. Moorjani· 2 shared A. Bloemendal· 1 shared A. Dey· 1 shared A. Garcia· 1 shared A. R. Martin· 1 shared B. Dhagat· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersEvolutionary Biology

A. Ganna

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Author profile →

6 papers

Recent·Most cited

50,000 years of Evolutionary History of India: Insights from ~2,700 Whole Genome Sequences

E. Kerdoncuff, L. Skov, N. Patterson, W. Zhao, Y. Y. Lueng, G. D. Schellenberg, J. A. Smith, S. Dey, A. Ganna, A. Dey, S. L. R. Kardia, J. Lee, P. Moorjani

This study analyzes 2,762 whole genome sequences from diverse Indian populations to reconstruct 50,000 years of evolutionary history, revealing major admixture events and archaic hominin gene flow.

bioRxiv · Feb 15, 2024 · PreprintEvolutionary Biology

A Light sheet fluorescence microscopy and machine learning-based approach to investigate drug and biomarker distribution in whole organs and tumors.

N. Kumar, P. Hrobar, M. Vagenknecht, J. Soukup, N. Patterson, P. Bloomingdale, T. Freshwater, S. Bardehle, R. Peter, R. Mangadu, C. V. Pastuskovas, C. Y. Chabu, M. T. Cancilla

This paper uses light sheet fluorescence microscopy and machine learning to study drug and biomarker distribution in whole organs and tumors, showing improved segmentation accuracy and subcellular resolution.

bioRxiv · Sep 16, 2023 · PreprintCancer Biology

Reconstructing the spatiotemporal patterns of admixture during the European Holocene using a novel genomic dating method

M. Chintalapati, N. Patterson, P. Moorjani

This paper introduces DATES, a genomic dating method to infer admixture timing in ancient genomes, revealing key migration events in Europe during the Holocene.

bioRxiv · Jan 18, 2022Evolutionary Biology

Combining Plasma Extracellular Vesicle Let-7b-5p, miR-184 and Circulating miR-22-3p Levels for NSCLC Diagnosis and Drug Resistance Prediction

G. P. Vadla, B. Dhagat, A. Garcia, G. Perez, V. Ahmad, N. Patterson, Y. Manjunath, J. Kaifi, G. Li, C. Y. Chabu

This study identifies a miRNA biomarker signature combining plasma extracellular vesicle and circulating miRNAs to improve NSCLC diagnosis and predict resistance to Osimertinib.

bioRxiv · Aug 15, 2021Cancer Biology

ContamLD: Estimation of Ancient Nuclear DNA Contamination Using Breakdown of Linkage Disequilibrium

N. J. Nakatsuka, E. Harney, S. Mallick, M. Mah, N. Patterson, D. E. Reich

ContamLD estimates ancient DNA contamination by analyzing linkage disequilibrium breakdown, showing accurate contamination rate inference with low error in simulated data.

bioRxiv · Feb 6, 2020Evolutionary Biology

Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies

M. Sohail, R. M. Maier, A. Ganna, A. Bloemendal, A. R. Martin, M. C. Turchin, C. W. K. Chiang, J. N. Hirschhorn, M. J. Daly, N. Patterson, B. M. Neale, I. Mathieson, D. Reich, S. R. Sunyaev

The paper shows that polygenic adaptation signals for height are overestimated due to uncorrected population structure in GWAS data.

bioRxiv · Jul 9, 2018Evolutionary Biology