A. R. Martin

Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis

The paper identifies two compounds that target GPX4 and TXNRD1 to induce apoptosis and ferroptosis in AML cells, effectively eradicating malignant cells while sparing normal hematopoietic cells.

High throughput screening of Leaf Economics traits in six wine grape varieties

This study uses reflectance spectroscopy and PLSR to predict leaf traits in six wine grape varieties, finding strong predictions for some traits but not others.

MCB-613 exploits a collateral sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1

The paper identifies MCB-613 as a compound that targets KEAP1 in EGFR inhibitor-resistant NSCLC cells, exploiting its selective essentiality through covalent inhibition.

Quaternary climate change explains global patterns of tree beta-diversity

The paper examines how Quaternary climate change influences tree beta-diversity globally, finding temperature changes since the Last Glacial Maximum strongly affect turnover and nestedness components.

Paleoclimate and current climate collectively shape the phylogenetic and functional diversity of trees worldwide

The paper maps global tree diversity patterns and shows that both current and ancient climates influence tree species richness, functional, and phylogenetic diversity.

Global Root Traits (GRooT) Database

The paper creates the Global Root Trait (GRooT) Database to integrate root trait data into large-scale analyses by standardizing and curating root trait records from diverse studies.

Half of the world's tree biodiversity is unprotected and is increasingly threatened by human activities

The paper identifies priority areas for global tree conservation and finds that half are unprotected and face human threats.

Crops and the seed mass-seed output trade-off in plants

This study shows domestication has altered the seed mass-seed output trade-off in crops compared to wild plants, with maize and soy exhibiting different evolutionary responses to selection pressures.

Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies

The paper shows that polygenic adaptation signals for height are overestimated due to uncorrected population structure in GWAS data.