Overcoming migratory exhaustion: Expression of Matrix metalloproteinase-8 (MMP-8) promotes tumor infiltration and anti-tumor activity of CAR-T cells
I. N. Bandey, M. J. Montalvo, H. Singh, N. Varadarajan
This study shows that CAR-T cells engineered to secrete MMP-8 enhance tumor infiltration and anti-tumor activity in solid tumors.