Repression of Hypoxia-Inducible Factor-1 Contributes to Increased Mitochondrial Reactive Oxygen Species Production in Diabetes
X. Zheng, S. Narayanan, C. Xu, S. Eliasson Angelstig, J. Grünler, A. Zhao, A. Di Toro, L. Bernardi, M. Mazzone, P. Carmeliet, M. Del Sole, G. Solaini, E. A. Forsberg, A. Zhang, K. Brismar, , S.-B. Catrina
This study shows that hyperglycemia represses HIF-1, leading to increased mitochondrial ROS production and renal injury in diabetes, which can be mitigated by restoring HIF-1 function.
bioRxiv · Jun 15, 2021Cell Biology