Author

P. Carmeliet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2

Frequent Co-Authors

D. Lambrechts· 2 shared J. Fernandez-Garcia· 2 shared J. Van Elsen· 2 shared M. Mazzone· 2 shared S.-M. Fendt· 2 shared T. Van Brussel· 2 shared A. A. Pane· 1 shared A. Alhendi· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

D. Lambrechts

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Prenatal VEGF Nano-Delivery Reverses Congenital Diaphragmatic Hernia-Associated Pulmonary Abnormalities

S. Loukogeorgakis, F. Michielin, S. Shibuya, N. Al-Juffali, J. Jimenez, J. Allen-Hyttinen, P. Eastwood, A. Alhendi, J. Davidson, E. Naldi, P. Maghsoudlou, A. Tedeschi, S. Khalaf, A. Khabbush, M. Plate, , P. De Coppi

This paper investigates VEGF supplementation as a treatment for congenital diaphragmatic hernia (CDH)-associated lung abnormalities using an ex vivo model and nanoparticle-based delivery in vivo.

bioRxiv · Feb 20, 2024Bioengineering

Weak neuronal glycolysis sustains cognition and organismal fitness

D. Jimenez-Blasco, J. Agulla, R. Lapresa, M. Garcia-Macia, V. Bobo-Jimenez, D. Garcia-Rodriguez, I. Manjarres-Raza, E. Fernandez, Y. Jeanson, S. Khoury, J.-C. Portais, D. Padro, P. Ramos-Cabrer, P. Carmeliet, A. Almeida, J. P. Bolanos

This study shows that weak neuronal glycolysis supports cognition and organismal fitness by preventing mitochondrial redox stress and maintaining autophagy.

bioRxiv · Sep 2, 2023Cell Biology

CD8+ T Cell Metabolic Rewiring Defined by Single-Cell RNA-Sequencing Identifies a Critical Role of ASNS Expression Dynamics in T Cell Differentiation

J. Fernandez-Garcia, F. Franco, S. Parik, A. A. Pane, D. Broekaert, J. Van Elsen, I. Vermeire, T. Van Brussel, R. Schepers, E. Modave, T. Karakach, P. Carmeliet, D. Lambrechts, P.-C. Ho, S.-M. Fendt

This study uses scRNA-seq to analyze CD8+ T cell metabolic dynamics during activation and differentiation, identifying ASNS expression dynamics as critical for determining T cell fate.

bioRxiv · Jul 27, 2021Immunology

Repression of Hypoxia-Inducible Factor-1 Contributes to Increased Mitochondrial Reactive Oxygen Species Production in Diabetes

X. Zheng, S. Narayanan, C. Xu, S. Eliasson Angelstig, J. Grünler, A. Zhao, A. Di Toro, L. Bernardi, M. Mazzone, P. Carmeliet, M. Del Sole, G. Solaini, E. A. Forsberg, A. Zhang, K. Brismar, , S.-B. Catrina

This study shows that hyperglycemia represses HIF-1, leading to increased mitochondrial ROS production and renal injury in diabetes, which can be mitigated by restoring HIF-1 function.

bioRxiv · Jun 15, 2021Cell Biology

Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis

M. Rossi, G. Doglioni, L. Bornes, D. Broekart, M. Planque, J. Fernandez-Garcia, G. Rinaldi, J. Van Elsen, D. Nittner, C. Jauset, F. Rizzollo, C. Riera Domingo, M. Orth, L. E. Dobrolecki, T. Van Brussel, , S.-M. Fendt

This study identifies PHGDH protein expression heterogeneity as a driver of breast cancer metastasis by altering metabolic pathways and promoting dissemination.

bioRxiv · Jan 24, 2021Cancer Biology