Cell BiologybioRxiv
Repression of Hypoxia-Inducible Factor-1 Contributes to Increased Mitochondrial Reactive Oxygen Species Production in Diabetes
X. Zheng, S. Narayanan, C. Xu…·S.-B. Catrina
This study shows that hyperglycemia represses HIF-1, leading to increased mitochondrial ROS production and renal injury in diabetes, which can be mitigated by restoring HIF-1 function.
DOI 10.7554/elife.70714