Author

I. R. Outhwaite

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

B.-T. Berger· 1 shared J. D. Chodera· 1 shared L. Pedi· 1 shared M. A. Seeliger· 1 shared S. B. Long· 1 shared S. Knapp· 1 shared S. Singh· 1 shared X. Hou· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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1 shared paperPharmacology & Toxicology

B.-T. Berger

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivJan 13, 2023

Death by a Thousand Cuts -- Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology

I. R. Outhwaite, S. Singh, B.-T. Berger…·M. A. Seeliger

This paper presents a method to improve kinase inhibitor selectivity by combining inhibitors with divergent off-target activities, validated using a NanoBRET assay.

DOI 10.7554/elife.86189

proteomicsdeep learning

𝕏 PostBluesky

BiochemistrybioRxivSep 3, 2020

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

X. Hou, I. R. Outhwaite, L. Pedi, S. B. Long

The paper presents a cryo-EM structure of the Orai channel in an open conformation, revealing the mechanism of channel opening and its role in Ca2+ entry regulation.

DOI 10.7554/elife.62772

Drosophilacryo-EM

𝕏 PostBluesky