ImmunologybioRxiv
Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses
J. Lee, J. Zhang, Y.-J. Chung…·E. Raz
The paper shows that cAMP-PKA-CREB signaling in cDC2s represses IRF4 and KLF4, promoting Th17 responses and inhibiting Th2, with similar effects observed through PRR-dependent signals like curdlan.
DOI 10.7554/elife.49416