J. H. Kim

Structural insights into CXCR4 modulation and oligomerization

This study uses cryoEM to reveal structural details of CXCR4 activation by CXCL12 and its oligomerization, showing new modes of GPCR regulation.

Genomic hypomethylation in cell-free DNA predicts responses to checkpoint blockade in lung and breast cancer

This study develops iMethyl, a method to estimate genomic hypomethylation from cell-free DNA to predict responses to immune checkpoint blockade in cancer patients.

SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling

This study identifies SARS-CoV-2 NSP13 as a suppressor of Hippo-YAP signaling by interacting with TEAD and remodeling chromatin to inhibit YAP transcriptional activity.

Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis

This study shows that warm temperatures suppress systemic acquired resistance in plants by reducing N-hydroxypipecolic acid biosynthesis, affecting both local and systemic immunity.

Calcium Sulfate Microparticle Size Modification for Improved Alginate Hydrogel Fabrication and Its Application in 3D Cell Culture

The paper shows that ball-milled calcium sulfate microparticles improve alginate hydrogel fabrication by creating more stable suspensions, leading to homogeneous gels with consistent mechanical properties for 3D cell culture.

The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

The secreted midbody remnants, MBsomes, as a new class of mRNA nanocarrier applicable to diverse medical fields

The paper identifies MBsomes as mRNA nanocarriers capable of delivering genes and expresses EGFP when loaded with mRNA.

A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Range of Human and Viral CaaX Sequences

The paper develops humanized yeast strains expressing human prenyltransferases to study prenylation of diverse CaaX sequences from human and viral proteins.

Small extracellular vesicles promote stiffness-mediated metastasis

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

Hyperglycosylation of prosaposin in tumor DCs promotes immune escape in cancer

This study shows that hyperglycosylation of prosaposin in tumor DCs leads to immune escape by impairing antigen presentation and T cell activation.

FluoMALDI microscopy: matrix co-crystallization simultaneously enhances fluorescence and MALDI imaging

This paper introduces FluoMALDI microscopy, which enhances fluorescence and MALDI imaging by co-crystallizing fluorophores with MALDI matrices, enabling simultaneous high-resolution imaging of the same tissue sections.

RaMALDI: enabling simultaneous Raman and MALDI imaging of the same tissue section

This paper introduces RaMALDI, a method that combines Raman and MALDI imaging on a single tissue section to integrate molecular information from both modalities.

Ambient temperature crystal structure of Escherichia coli CyaY protein displays alternate conformation

The paper presents the first ambient temperature crystal structure of Escherichia coli CyaY, revealing an alternate conformation and highlighting temperature's impact on protein structure.

De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

This study shows that de novo fatty-acid synthesis via ACC1 prevents iNKT cell death and promotes their pathogenic roles in allergic asthma.

Discovery and biosynthesis of imidazolium antibiotics from a probiotic Bacillus licheniformis

The paper identifies a novel imidazolium antibiotic from Bacillus licheniformis and proposes its biosynthetic pathway through various experimental methods.

Non-Invasive Cancer Detection in Canine Urine through C. elegans Chemotaxis

This study demonstrates a non-invasive cancer detection method using C. elegans chemotaxis to canine urine, achieving 85% sensitivity and 93% specificity for common canine cancers.

An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant

This study uses untargeted metabolomics to analyze exogenous chemicals in human milk and finds they are present in newborn stool, indicating potential infant exposure through breastfeeding.

Exploring ensemble structures of Alzheimer's amyloid β (1-42) monomer using linear regression for the MD simulation and NMR chemical shift

This paper uses linear regression with NMR and MD simulation data to determine ensemble structures of Alzheimer's Aβ monomers, revealing β-sheet and partially-helical conformations and their implications for amyloidogenesis.

Therapeutic base and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa

This study corrects COL7A1 mutations in RDEB patient fibroblasts using base and prime editing, restoring C7 expression and function in vitro and in vivo.

ROCK1 regulates insulin secretion from β-cells

This study shows that ROCK1 is essential for glucose-stimulated insulin secretion in β-cells and regulates pyruvate kinase signaling.

Hemangiosarcoma Cells Promote Conserved Host-Derived Hematopoietic Expansion

This study shows that hemangiosarcoma cells create a microenvironment that supports hematopoietic expansion, resembling bone marrow niche cells.

Prime editing enables precise genome editing in mouse liver and retina

This study demonstrates that prime editing can correct disease-causing mutations in adult mouse liver and retina, with minimal off-target effects.

Deep Learning Identification of Stiffness Markers in Breast Cancer

This study uses deep learning to identify stiffness markers in breast cancer tissue, finding that straight collagen percentage best correlates with tissue stiffness.

Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defects

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

Newly developed silicone airway stent (GINA stent): Mechanical characteristics and performance evaluation in pigs

The paper evaluates a new silicone airway stent (GINA stent) in pigs, showing improved mechanical properties and comparable performance to the Dumon stent.

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

This study identifies novel fusion genes in human angiosarcomas and canine hemangiosarcomas, showing convergent transcriptional programs driven by these fusions and mutations in TP53 and PI3K/AKT/mTOR pathway genes.

Rapid Establishment of Tracheal Stenosis in Pigs Using Endotracheal Tube Cuff Overpressure and Electrocautery

This paper develops a rapid tracheal stenosis model in pigs using cuff overpressure and electrocautery, achieving stenosis in 7 days with combined treatment.

S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell-cell interactions with adjacent breast cancer cells.

This study shows that S100A8/A9 mediates the reprogramming of normal mammary epithelial cells by dynamic interactions with breast cancer cells, leading to epithelial-mesenchymal transition and altered cellular behaviors.

Adolescent rats show estrous cycle-mediated sex differences in extinction of conditioned fear

This study shows adolescent female rats in estrous phases with high estradiol levels show delayed fear extinction compared to males and ovariectomized females.

An original structural fold underlies the multitask P1, a silencing suppressor encoded by the Rice yellow mottle virus

The paper determines the 3D structure and dynamics of P1, a silencing suppressor from Rice Yellow Mottle virus, revealing structural features and their roles in viral infectivity.