Author

I. S. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

E. T. Roussos-Torres· 2 shared C. Hodgdon· 1 shared C. Smith· 1 shared E. H. Chen· 1 shared H. Knutsdottir· 1 shared H. L. McArthur· 1 shared J. Maues· 1 shared J. Pena· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

E. T. Roussos-Torres

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations

K. Lake, M. Colonetta, C. Smith, K. Martinez-Algarin, K. Saunders, S. Mohta, J. Pena, H. L. McArthur, S. M. Reddy, E. T. Roussos-Torres, E. H. Chen, I. S. Chan

The paper identifies copy number amplifications in metastatic breast tumors and validates FGFR1 amplification in migrating organoids, showing organoids capture tumor genetic heterogeneity.

bioRxiv · Jan 29, 2023 · PreprintCancer Biology

A comprehensive single-cell breast tumor atlas defines cancer epithelial and immune cell heterogeneity and interactions predicting anti-PD-1 therapy response

L. Xu, K. N. Saunders, H. Knutsdottir, K. Chen, J. Maues, C. Hodgdon, E. T. Roussos-Torres, S. Reddy, L. Xu, I. S. Chan

The paper defines cancer epithelial and immune cell heterogeneity in breast tumors using single-cell RNA-seq and develops a tool to predict anti-PD-1 therapy response.

bioRxiv · Aug 1, 2022 · PreprintCancer Biology