S. Reddy

Individualized AI-driven Neuromodulation Selectively Enhances and Reorganizes Human Tongue Sensorimotor Networks.

This paper introduces an AI-driven neuromodulation platform that enhances and reorganizes human tongue sensorimotor networks by targeting individual network architecture.

Individualized AI-driven neuromodulation enhances tongue motor and sensory control networks: a platform for neurorehabilitation in cancer survivors and patients with neurodegenerative disease.

This paper introduces an AI-driven fMRI neuromodulation platform that enhances sensorimotor control networks in healthy participants, showing improved signal strength and network expansion with functional persistence.

qMAP Enabled Microanatomical Mapping of Human Skin Aging

This study introduces qMAP, a deep learning-based workflow for microanatomical mapping of human skin, identifying 10 core processes strongly associated with aging and achieving age prediction accuracy comparable to epigenetic clocks.

Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma

This study establishes mouse models of Cdk5-driven Medullary Thyroid Carcinoma (MTC) that recapitulate human tumor aggressiveness and identifies metabolic pathway perturbations as critical for aggressive growth.

Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory Metabolites

This study shows exercise reduces flow recirculation and activates SCD1 to produce anti-inflammatory metabolites in endothelial cells.

Dietary sugar and protein exert opposing effects on key larval growth and metabolic regulators, the Drosophila insulin-like peptides Dilp2 and Dilp6.

This study shows that dietary sugar and protein oppositely regulate Dilp2 and Dilp6 in Drosophila larvae, affecting growth and metabolism through distinct mechanisms.

Bill shape imposes biomechanical tradeoffs in cavity-excavating birds

This study examines biomechanical tradeoffs in bill shapes of cavity-excavating birds, finding that deeper and wider bills resist impact better but perform worse under torsion.

Climate influences bill shape diversification in cavity-excavating birds

This study examines how climate influences bill shape diversification in cavity-excavating birds, finding that maxillary shape correlates with climate variables and shows allometric scaling.

A comprehensive single-cell breast tumor atlas defines cancer epithelial and immune cell heterogeneity and interactions predicting anti-PD-1 therapy response

The paper defines cancer epithelial and immune cell heterogeneity in breast tumors using single-cell RNA-seq and develops a tool to predict anti-PD-1 therapy response.

Plasticity of the proteasome-targeting signal Fat10 enhances substrate degradation

This study shows that the structural plasticity of the Fat10 proteasome-targeting tag enhances substrate degradation by creating partially unstructured regions and reducing resistance to mechanical unfolding.

Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Cancer

This paper shows that loss of SDHB in adrenal neuroendocrine cancer disrupts bioenergetic sensing through Cdk5 activation, leading to tumor progression, and that Cdk5 inhibition can reverse this process.

Patterns of morphological diversification in the Ramphastoidea reveal the dramatic divergence of toucans from a conserved morphotype

The paper analyzes morphological diversification in toucans and barbets across three continents, finding a conserved morphotype with toucans diverging into a distinct trait space.

Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors

This paper develops a mouse model of PanNETs driven by Cdk5 and shows its relevance to human tumors, supporting Cdk5 as a therapeutic target.

Inactivation of SARS-CoV-2 by β-propiolactone Causes Aggregation of Viral Particles and Loss of Antigenic Potential

This study examines the effects of β-propiolactone on SARS-CoV-2 inactivation, finding that higher concentrations cause protein loss, antigenic degradation, and virion aggregation.

Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor

This study shows that combining AKT and KIT inhibitors restores PDCD4 expression in GIST cells, leading to cell death, but the combination is less effective in IM-resistant models.

Development of Equine Immunoglobulin Fragment F(ab')2 with High Neutralizing Capability against SARS-CoV-2

This study develops equine-derived F(ab')2 antibodies with high neutralizing capability against SARS-CoV-2, showing effectiveness against viral variants.

Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells

This study identifies immune cell states in pancreatic cancer, showing regulatory T-cells and dysfunctional CD8+ T-cells contribute to a suppressive microenvironment, suggesting new therapeutic targets.

Human intestinal tissue-resident memory CD8+ T cells comprise transcriptionally and functionally distinct subsets

This study identifies transcriptionally and functionally distinct subsets of human intestinal TRM cells, with β2-integrin marking a unique CD8+ TRM population.

Diversification of a cryptic radiation, a closer look at Madagascar’s recently recognized bird family

The paper presents a comprehensive phylogeny of the Bernieridae family to examine its diversification history and discover cryptic species within it.

Phosphoprotein-based Biomarkers as Predictors for Cancer Therapy

The paper identifies phosphoprotein biomarkers for Cdk5 activity in neuroendocrine tumors and shows their predictive value for anti-Cdk5 therapy.

Preparation of Artesunate mPEG-PLGA Nanoparticles and Its Application to K562 Apoptosis of cells

This paper prepares artesunate-loaded mPEG-PLGA nanoparticles and shows they inhibit K562 cell proliferation and induce apoptosis more effectively than free artesunate.