Author

I. Sekirov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:cryo-EM· 1 Approach:statistical model· 1 Assay:structural biology· 1 Research Focus:variant calling· 1 Organism:virus· 1

Frequent Co-Authors

A. M. Berezuk· 2 shared D. Mannar· 2 shared J. W. Saville· 2 shared K. Tuttle· 2 shared S. S. Srivastava· 2 shared S. Subramaniam· 2 shared X. Zhu· 2 shared A. Kim· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

A. M. Berezuk

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Whole Genome Sequencing based Identification of Human Tuberculosis caused by Animal-lineage Mycobacterium orygis

M. R. Islam, M. K. Sharma, R. KhunKhun, C. Shandro, I. Sekirov, G. J. Tyrrell, H. Soualhine

This study identifies unique SNPs in M. orygis using WGS to distinguish it from other MTBC species and provides genetic markers for accurate identification.

bioRxiv · Feb 27, 2023 · PreprintMicrobiology

SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion

D. Mannar, J. W. Saville, X. Zhu, S. S. Srivastava, A. M. Berezuk, K. Tuttle, C. Marquez, I. Sekirov, S. Subramaniam

This study analyzes the Omicron variant's ACE2 binding and antibody evasion using Cryo-EM and neutralization assays, finding similar ACE2 binding affinity to Delta and increased antibody evasion.

bioRxiv · Dec 19, 2021 · PreprintBiochemistry

Structural and Biochemical Rationale for Enhanced Spike Protein Fitness in Delta and Kappa SARS-CoV-2 Variants

J. W. Saville, D. Mannar, X. Zhu, S. S. Srivastava, A. M. Berezuk, J.-P. Demers, S. Zhou, K. Tuttle, I. Sekirov, A. Kim, W. Li, D. S. Dimiter, S. Subramaniam

This study examines structural and biochemical features of Delta and Kappa SARS-CoV-2 variants, showing increased ACE2 binding and antibody escape, contributing to Delta's dominance.

bioRxiv · Sep 2, 2021Biochemistry