Author

J.-P. Demers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2

Frequent Co-Authors

D. Mannar· 2 shared K. Tuttle· 2 shared S. S. Srivastava· 2 shared S. Subramaniam· 2 shared S. Zhou· 2 shared W. Li· 2 shared X. Zhu· 2 shared A. Berezuk· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersBiochemistry

D. Mannar

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2 papers

Recent·Most cited

Structural and Biochemical Rationale for Enhanced Spike Protein Fitness in Delta and Kappa SARS-CoV-2 Variants

J. W. Saville, D. Mannar, X. Zhu, S. S. Srivastava, A. M. Berezuk, J.-P. Demers, S. Zhou, K. Tuttle, I. Sekirov, A. Kim, W. Li, D. S. Dimiter, S. Subramaniam

This study examines structural and biochemical features of Delta and Kappa SARS-CoV-2 variants, showing increased ACE2 binding and antibody escape, contributing to Delta's dominance.

bioRxiv · Sep 2, 2021Biochemistry

Cryo-EM Structures of the N501Y SARS-CoV-2 Spike Protein in Complex with ACE2 and Two Potent Neutralizing Antibodies

X. Zhu, D. Mannar, S. S. Srivastava, A. Berezuk, J.-P. Demers, J. Saville, K. Leopold, W. Li, D. S. Dimitrov, K. Tuttle, S. Zhou, S. Chittori, S. Subramaniam

The paper presents cryo-EM structures of the N501Y SARS-CoV-2 spike protein complex with ACE2 and neutralizing antibodies, showing increased ACE2 binding affinity and retained epitopes.

bioRxiv · Jan 11, 2021 · PreprintBiophysics