Cancer BiologybioRxiv
Genome-wide silencing screen in mesothelioma cells reveals that loss of function of BAP1 induces chemoresistance to ribonucleotide reductase inhibition: implication for therapy
A. Okonska, S. Buehler, V. Rao…·E. Felley-Bosco
The paper identifies BAP1's role in regulating RRM2 during replication stress, showing that BAP1 loss increases chemoresistance to ribonucleotide reductase inhibitors in mesothelioma cells.
DOI 10.1158/1535-7163.mct-19-0356