Genome-wide silencing screen in mesothelioma cells reveals that loss of function of BAP1 induces chemoresistance to ribonucleotide reductase inhibition: implication for therapy
A. Okonska, S. Buehler, V. Rao, M. Ronner, M. Blijlevens, I. Van der Meulen-Muileman, R. de Menezes, E. Smit, W. Weder, R. Stahel, L. Penengo, V. van Beusechem, E. Felley-Bosco
The paper identifies BAP1's role in regulating RRM2 during replication stress, showing that BAP1 loss increases chemoresistance to ribonucleotide reductase inhibitors in mesothelioma cells.
bioRxiv · Jul 31, 2018Cancer Biology