Induction of Human Pruriceptors from Pluripotent Stem Cells via Transcription Factors
Hisato Iriki, Ruiqi Hu, Xu Li, Erdene Baljinnyam, Carina Habich, Ichiro Imanishi, Loan N. Miller, Kavya Chegireddy, Laraib Iqbal Malik, Daniel Yassky, Raphael Kübler, Aaron Ver Heul, Kathleen M. Smith, Peter Reinhardt, Eric R. Goedken, , Samuele G. Marro
This paper develops a method to generate functional human pruriceptors from pluripotent stem cells using transcription factors, showing they respond to itch stimuli and drugs like ABT-317.
Stem Cell Reports · Jul 9, 2026Peer-reviewedNeuroscience