Brian Kim

Induction of Human Pruriceptors from Pluripotent Stem Cells via Transcription Factors

This paper develops a method to generate functional human pruriceptors from pluripotent stem cells using transcription factors, showing they respond to itch stimuli and drugs like ABT-317.

NGN2 Expression and Regional Patterning Allow Rapid Differentiation from hiPSCs to DRG-Like Neurons Responsive to Type 2 Cytokines

This study generates DRG-like neurons from hiPSCs using NGN2 overexpression and patterning factors, which respond to type 2 cytokines involved in itch.

RAG suppresses group 2 innate lymphoid cells

This study shows that RAG suppresses group 2 innate lymphoid cells (ILC2s), affecting their cytokine production and contributing to inflammation in atopic dermatitis.

MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel

The paper identifies TRPV1+/MrgprA3+ prurioceptors and Piezo2 channel signaling as drivers of pruritogen-induced alloknesis.

Macrophage-to-sensory neuron crosstalk mediated by Angiotensin II type-2 receptor elicits neuropathic pain

This study identifies macrophage AT2R activation as a key driver of neuropathic pain through ROS/NO-mediated TRPA1 activation in sensory neurons.