Samuele G. Marro

KMT2E recruitment by H3 serotonylation regulates neurodevelopmental chromatin dynamics

This study identifies KMT2E as a reader of H3K4me3Q5ser, showing its role in regulating chromatin dynamics and neurodevelopmental gene expression in ODLURO syndrome.

Induction of Human Pruriceptors from Pluripotent Stem Cells via Transcription Factors

This paper develops a method to generate functional human pruriceptors from pluripotent stem cells using transcription factors, showing they respond to itch stimuli and drugs like ABT-317.

Quinone reductase 2 reads H3 serotonylation to support human cortical neuron development

This study identifies QR2 as a reader of H3Q5ser, showing its role in human neuron development through transcriptional and electrophysiological effects.

NGN2 Expression and Regional Patterning Allow Rapid Differentiation from hiPSCs to DRG-Like Neurons Responsive to Type 2 Cytokines

This study generates DRG-like neurons from hiPSCs using NGN2 overexpression and patterning factors, which respond to type 2 cytokines involved in itch.

Mosaic chromosomal alterations in blood are associated with an increased risk of Alzheimer's disease

The paper finds that mosaic chromosomal alterations in blood are associated with increased Alzheimer's disease risk, with variations by ancestry, mCA subtype, APOE ε4 status, and chromosomal location.

Hippocampal γCaMKII dopaminylation promotes synaptic-to-nuclear signaling and memory formation

The paper identifies dopaminylated proteins in the brain, including γCaMKII, and shows its role in synaptic-to-nuclear signaling and memory formation.

Single-cell genotype-phenotype mapping identifies therapeutic vulnerabilities in VEXAS syndrome

This study uses single-cell multi-omics to map genotype-to-phenotype relationships in VEXAS syndrome, identifying PERK pathway activation as a therapeutic target.

HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model

This paper describes a humanized mouse model using iPSC-derived microglia to study HIV-1 infection in the CNS, enabling genetic and therapeutic investigations in vivo.

BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer's disease and other disorders of lipid-rich tissues

This study identifies BHLHE40/41 as key regulators of macrophage/microglia responses in Alzheimer's disease and other lipid-rich tissue disorders through sc/nRNA-seq analysis and functional validation.