Kathleen M. Smith

This paper develops a method to generate functional human pruriceptors from pluripotent stem cells using transcription factors, showing they respond to itch stimuli and drugs like ABT-317.

The paper identifies treatment response-associated cell subpopulations in autoimmune diseases by integrating single-cell and bulk data from IBD and PsO patients, revealing key pathways and cell types involved in response or non-response.

This study generates DRG-like neurons from hiPSCs using NGN2 overexpression and patterning factors, which respond to type 2 cytokines involved in itch.

This paper introduces JECCA, a method for identifying shared biological signals across gene expression datasets, enabling disease subtyping, biomarker discovery, and cross-species analysis.

This study conducts a multi-ancestry GWAS meta-analysis of 56,146 AD cases and 602,280 controls, identifying 101 genomic loci, 15 novel to AD or eczema, and linking them to AD pathophysiology through functional analyses.