The ciliary protein IFT88 controls post-natal cartilage thickness and influences development of osteoarthritis.
Clarissa R. Coveney, Linyi Zhu, Jadwiga Miotla‐Zarebska, B. Stott, Ida Parisi, Vicky Batchelor, C. Duarte, Emer Chang, Eleanor McSorley, Tonia L. Vincent, Angus K. T. Wann
This study shows that IFT88 deletion leads to reduced cartilage thickness and increased osteoarthritis in mice, with exercise partially reversing these effects.
Arthritis & Rheumatology · Jun 9, 2021Peer-reviewedMolecular Biology