Angus K. T. Wann

This study investigates cilia orientation and centriole positioning in growing limbs, finding that cilia orientation is preferentially organized and independent of centriole position or mechanical loading.

This study shows mitochondrial heteroplasmy impairs osteoclast differentiation and bone resorption by disrupting respiratory complex I and autophagy, and identifies spermidine as a potential therapeutic.

The paper uses in vivo pulsed SILAC to measure protein incorporation in mice tissues, finding reduced turnover and molecular changes linked to aging.

This study shows that IFT88 deletion leads to reduced cartilage thickness and increased osteoarthritis in mice, with exercise partially reversing these effects.