Author
University of PennsylvaniaORCID 0000-0003-4918-6179Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Ling Wu, Kimberly A. Wodzanowski, Stephanie M Schreiner…·Sunny Shin
This study shows human CASP4 and CASP5 form SMOCs in response to LPS structures that evade TLR4 and Casp11, revealing their distinct roles in sensing bacterial LPS and implications for sepsis therapy.
Matthew E. Sherman, Colton Sheehan, Luca Musante…·Sunny Shin
This study shows that the polysaccharide portion of LPS, not just lipid A acylation, is critical for Casp11 inflammasome activation and pyroptosis.
Stefan T. Peterson, Katherine G. Dailey, Karthik Hullahalli…·Igor E. Brodsky
This study shows that small bacterial founder populations independently colonize intestinal and systemic tissues during Yersinia infection, with TNF signaling restricting dissemination.