Conditional CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors
Nastaran Khazamipour, Htoo Zarni Oo, Nader Al-Nakouzi, Mona Marzban, Nasrin Khazamipour, Morgan E. Roberts, Negin Farivar, Igor Moskalev, Joey Lo, Fariba Ghaidi, Irina Nelepcu, Alireza Moeen Rezakhanlou, Sarah Truong, Robert Dagil, Swati Choudhary, , Mads Daugaard
This study develops CAR T cells specific to oncofetal chondroitin sulfate, demonstrating their ability to target and eliminate tumor cells in vitro and improve survival in vivo.
EMBO Molecular Medicine · Oct 15, 2024Peer-reviewedCancer Biology