C. elegans huntingtin, htt-1, promotes robust autophagy induction and survival under stress conditions
Christine Hyein Chung, Hanee Lee, Kyumin Park, Young Seo Park, Roy Jung, Ihnsik Seong, Junho Lee
This paper shows that C. elegans htt-1 promotes survival under stress by inducing autophagy, with wild-type human HTT rescuing survival defects and mutant HTT worsening them.
bioRxiv · Dec 1, 2024 · PreprintCell Biology