Dual inhibition of glutaminolysis and autophagy suppresses proliferation of Rheumatoid arthritis fibroblast-like synoviocytes and mitigates arthritis in SKG mice
Ikuko Naka, Sho Sendo, T. Okano, Kenichi Uto, Soshi Takahashi, Shinya Hayashi, Ryosuke Kuroda, Akio Morinobu, Jun Saegusa
This study shows that inhibiting both glutaminolysis and autophagy reduces RA-FLS proliferation and arthritis in SKG mice.
bioRxiv · Jun 25, 2025 · PreprintImmunology