Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs
Emilia Vartiainen, Dhara Liyanage, Illinca Mazureac, Rachel A. Battaglia, Matthew Tegtmeyer, He Jax Xu, Noora Räsänen, Julia Sealock, Steven A. McCarroll, Ralda Nehme, Olli P. H. Pietiläinen
The paper shows that astrocyte-supplied cholesterol drives synaptic gene expression in neurons and induces astrocytic transcriptional responses, linking lipid metabolism to neurodevelopmental disorders.
bioRxiv · Jan 28, 2025 · PreprintMolecular Biology