Author

He Jax Xu

Broad InstituteORCID 0000-0002-9087-9041Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Cheng LiiD· 1 shared Dhara Liyanage· 1 shared Emilia VartiaineniD· 1 shared Fengxiang Tan· 1 shared Illinca Mazureac· 1 shared Jiaoyang LiaoiD· 1 shared Jinsong LiiD· 1 shared Julia SealockiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperDevelopmental Biology

Cheng LiORCID

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2 papers

Recent·Most cited

Gastrula-premarked posterior enhancer primes posterior tissue development through cross-talk with TGF-β signaling pathway

Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, , Xianfa Yang

The paper identifies a pre-marked enhancer, p-Enh, that primes posterior tissue development in mouse embryos through interaction with the TGF-β signaling pathway.

Advanced Science · Jun 29, 2025Peer-reviewedDevelopmental Biology

Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs

Emilia Vartiainen, Dhara Liyanage, Illinca Mazureac, Rachel A. Battaglia, Matthew Tegtmeyer, He Jax Xu, Noora Räsänen, Julia Sealock, Steven A. McCarroll, Ralda Nehme, Olli P. H. Pietiläinen

The paper shows that astrocyte-supplied cholesterol drives synaptic gene expression in neurons and induces astrocytic transcriptional responses, linking lipid metabolism to neurodevelopmental disorders.

bioRxiv · Jan 28, 2025 · PreprintMolecular Biology